This season, ABC moved Ugly Betty from Thursday, one of the best time slots available, to Friday. The move effectively put the show on its deathbed, and it has continued to fade into obscurity since the move to Fridays.
Now, ABC is reportedly trying some CPR. Ugly Betty is said to be moving from Friday to Wednesday as of January. Wednesday is sure better than Friday, but two schedule changes in one season typically does not bode well.